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The effect of apolipoprotein E and hypercholesterolemia on lipoproteins and amyloid metabolism
Author(s) -
ONG QiRui,
LIM MeiLi,
CHUA ChingChing,
WONG BoonSeng
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.823.12
Subject(s) - apolipoprotein e , medicine , endocrinology , lipoprotein , ldl receptor , cholesterol , amyloid (mycology) , apolipoprotein b , lipid metabolism , catabolism , biology , chemistry , metabolism , disease , botany
Apolipoprotein E (ApoE) is a major component of lipoprotein and has an important role in cholesterol homeostasis. ApoE is highly expressed in liver and brain. Altered apoE expression is associated with defective low‐density lipoprotein receptor (LDL‐R) and may cause hypercholesterolemia, a prominent feature in atherosclerosis and a growing risk factor for Alzheimer's disease (AD). Indeed, there is accumulating evidence demonstrating a pathogenic connection between atherosclerosis and AD. Animal studies showed that ApoE is involved in amyloid catabolism but the lack of ApoE can dramatically reduces amyloid‐beta (Aβ) deposition. In addition, ApoE also has anti‐atherogenic function and played an important role in the atherosclerotic process. However, the mechanisms underlying these contrasting properties in the liver and brain remained an enigma. In this study, we will present ApoE contribution to the biochemical profile of high‐density lipoprotein (HDL), LDL, triglycerides and cholesterol in control and ApoE‐null mice fed on a high‐fat diet. We will show that hypercholesterolemia affects Aβ production via modulating the expression of several enzymes involved in Aβ metabolism.