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Inducing Cartilage Regeneration with Stem Cells for Treatment of Osteoarthritis Patients
Author(s) -
Ferng Alice Shirong,
Ferguson Christopher William,
Szivek John A.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.819.1
Subject(s) - stem cell , osteoarthritis , chondrogenesis , cartilage , adipose tissue , stem cell transplantation for articular cartilage repair , medicine , bone marrow , adult stem cell , regeneration (biology) , microbiology and biotechnology , pathology , anatomy , chemistry , in vitro , biology , endothelial stem cell , biochemistry , alternative medicine
Osteoarthritis is a progressive disease characterized by breakdown and loss of articular cartilage, which results in joint pain, stiffness, and limitations in activity and affects millions of people worldwide. Although artificial joint replacements are currently the gold standard for osteoarthritis patients, they can cause problems, such as bone loss, pain if the implant becomes loose, and a loss of proprioception. Stem cells converted to cartilage cells (chondrocytes) can be used to induce cartilage regeneration. Stem cells isolated from adipose (fat) tissue can differentiate into chondrocytes under the appropriate conditions (Guilak et al . (2003). Cytotherapy 5(5):362–9). This project investigates the chondrocytic potentials of human stem cell lines in vitro isolated from: 1) adipose tissue, 2) bone marrow, and 3) umbilical cord blood. Growth factors, TGF‐β3 and BMP‐6, known to encourage chondrogenesis of stem cells have been used to treat these stem cell lines. Additionally, a pilot study with canine adipose‐derived stem cells is underway to determine how stem cells respond in vivo .