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Analysis of Genomic Instability in Colorectal Carcinoma
Author(s) -
Flaherty Patrick,
Davis Ronald W,
Ji Hanlee
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.798.4
Subject(s) - comparative genomic hybridization , colorectal cancer , genome instability , biology , oncology , cancer , medicine , genetics , genome , gene , dna , dna damage
We are studying the genetic differences between colorectal carcinoma and normal somatic cells to understand the genomic instability events that lead to cancer progression in order to diagnose invasive carinomas in early stage two patients. We have compiled array comparative genomic hybridization data from 212 clinical samples of colorectal carcinoma and conducted a meta‐analysis of the data to search for regions of significant genomic loss or gain. Using robust logistic regression and cross‐validation procedures, we have isolated several regions that are associated with poor clinical outcome. This analysis has provided key genomic loci that we are using to interrogate allele‐specific gene conversion and copy number aberration events in a prospective clinical trial.