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THE ASSOCIATION OF XENOBIOTIC METABOLISM GENES POLYMORPHISM IN BLADDER CANCER
Author(s) -
Altayli Ertan,
Gunes Sezgin,
Yilmaz Ali Faik,
Irkilata Hasan Cem
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.794.13
Subject(s) - gstp1 , bladder cancer , genotype , turkish population , cyp1a2 , cyp2d6 , allele , biology , oncology , glutathione s transferase , medicine , multiplex polymerase chain reaction , gene polymorphism , gene , genetics , cancer , polymerase chain reaction , glutathione , cytochrome p450 , metabolism , enzyme , biochemistry
The aim of this study was to investigate the relationship between bladder tumor and variants of cytocrom p450 1A2 (CYP1A2) C734A, CYP2D6 G1934A, glutathione s‐transferase P1 (GSTP1) I105V, GSTM1 null, and GSTT1 null which play an important role in xenobiotic metabolism. We investigated the distribution of these polymorphisms in 135 bladder cancer patients and 128 age‐matched healthy individuals as controls. The polymorphisms were analyzed using polymerase chain reaction‐restriction fragment length polymorphism assay and multiplex PCR method. Genotype and allele frequencies were calculated, and their associations with bladder cancer risk are assayed, and association with bladder cancer risk or demographic factors, smoking status, and tumor stage was investigated. The prevalence of GSTT1 null genotype in cases were 23%, compared to 7% in the control group (OR, 0.254, %95 CI, 0.115–0558, p = 0.001). No association was observed between CYP1A2, CYP2D6, GSTM1, and GSTP1 genes polymorphisms and bladder cancer. GSTT1 gene polymorphism may be associated with bladder cancer in a Turkish population studied. This research was supported by the Ondokuz Mayis University.