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Model simulation of expired CO2 from its alveolar distribution in parallel and series models
Author(s) -
Caucha Luis Jhony,
Cruz Julio Cesar,
Rueda Luis Antonio
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.763.6
Subject(s) - apex (geometry) , blood flow , lung , base (topology) , flow (mathematics) , distribution (mathematics) , series (stratigraphy) , dead space , mathematics , anatomy , medicine , geometry , geology , respiratory system , mathematical analysis , paleontology
The CO 2 model of Scherer (J. Appl. Physiol. 64:1022, 1988) is here applied to the 7 regions model of Jeng et al (Ann. Biomed. Eng. 28:453, 2000). While Scherer et al ended up with an alveolar CO 2 concentration of 3.1% and used a pulmonary blood flow of 100 mL/s, we applied West concept of less CO 2 and blood flow at the apex. The alveolar CO 2 concentrations and the pulmonary blood flow at the apex and base of the lung were: 2.6% and 4.4%; 1.2 mL/s and 41mL/s, respectively. The anatomical model of Weibel is scaled for each region The results are on the figure. Although the curves are similar, our curve shows a larger dead space and less slope of phase 3. The base of the lung contributes more to the onset of CO 2 in the capnogram. Supported in part by ONG‐Centro de Enseñanza, Investigación y Servicios.