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Delayed lung expansion following pneumonectomy (PNX) improves gas exchange during exercise
Author(s) -
Dane Dan Merrill,
Yilmaz Cuneyt,
Hsia Connie C.W.,
Johnson Robert L
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.763.10
Subject(s) - lung volumes , lung , cardiology , chemistry , medicine , anesthesia
To examine post‐PNX response to expansion of the remaining lung separate from that to other signals (perfusion or inflammation), the right lung of adult male foxhounds was replaced by a custom‐shaped inflated silicone prosthesis filled to end‐expiratory lung volume (EELV) with 50/50 SF 6 /air. The prosthesis was acutely deflated after 4mo (DEF, n=6) or kept inflated (INF, n=3). Lung volume (mL.kg −1 ), pulmonary blood flow (Q̇c, mL·(min·kg) −1 ), lung and membrane diffusing capacities (DL CO and DM CO , mL·[min·mmHg·kg] −1 ), and pulmonary capillary blood volume (Vc, ml.kg −1 ) were measured at exercise pre‐PNX and 4 and 12mo post‐PNX. Exercise Q̇c was unaltered. At the same Q̇c (=400), DL CO and DM CO were 25–40% below normal 4mo post‐PNX. By 12mo in INF group, EELV, DL CO and DM CO further declined 28, 10 and 25%, respectively, while in DEF group these values were 87, 32 and 73% higher relative to INF group. Vc changed variably. Mean ± SD. P<0.05 *vs. normal, †vs. INF 4mo, ‡vs. INF 12mo. Thus, delayed lung expansion post‐PNX significantly improved gas exchange at exercise. Supported by NHLBI R01 HL‐040070, 054060, 062873 and 045716.