Premium
Myocardial SIRT1 expression following endurance and resistance exercise training in young and old rats
Author(s) -
Cross Whitney L.,
Roby Mackenzie A.,
Deschenes Michael R.,
Harris M. Brennan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.753.1
Subject(s) - medicine , endurance training , endocrinology , body weight , treadmill , protein expression , resistance training , aerobic exercise , calorie restriction , biology , genetics , gene
Previous studies indicate a link between caloric restriction, SIRT1 expression, and longevity. It has been suggested that the metabolic stress of exercise may also alter SIRT1 expression. Therefore, we evaluated the effects of two different modes of exercise training on myocardial SIRT1 protein expression in young and old rats. In the first study, young (8 mo) and old (24 mo) Fisher 344 rats were subjected to a progressive treadmill training program for 10 wks ending at 60 min/day, 15 m/min, 0% grade. Myocardial SIRT1 expression was not significantly different ( P >0.05) between young and old rats. However, endurance training resulted in a significant ( P <0.05) decrease in myocardial SIRT1 protein expression. In the second study, young (5 mo) and old (22 mo) Fisher 344 rats were resistance trained by ladder climbing for 8 wks. Animals began by lifting 50% body weight and ended the training protocol lifting 276±6% body weight (young) and 141±12% body weight (old). Again, we observed no effect of age on myocardial SIRT1 expression. However, in contrast to endurance training, resistance training resulted in no significant ( P >0.05) change in SIRT1 expression. The results of this study demonstrate that exercise‐induced changes in myocardial SIRT1 expression are dependent on the mode of training. Supported by Borgenicht Program for Aging Studies and Exercise Science (MBH), AHA SDG 0430157N (MBH), and the NIA (MRD).