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A Protective effect of Taikong Xieli decoction, a traditional Chinese medicine, on the damage of HPAA in the rat induced by weightlessness and irradiation
Author(s) -
Ming Xie,
Lin Zhang
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.752.1
Subject(s) - decoction , hypothalamus , spaceflight , weightlessness , medicine , endocrinology , irradiation , chemistry , physics , astronomy , nuclear physics , engineering , aerospace engineering
The weightlessness and irradiation are the major factors that regulate physiological adaptive responses under the spaceflight environment. The aim of the study is to investigate the effect of Taikong Xieli decoction(TKXLD), a traditional Chinese medicine, on the alteration of HPAA in the rats induced by both weightlessness and irradiation. Wister rats were randomly divided into four groups, each with 12 rats control (C), tail suspended (S), tail suspended and irradiated (SAI) and TKXLD group. Simulated weightlessness and irradiation was induced by treatment with 4.5Gy of 60Co‐gamma rays on 8th day of tail suspended. The TKXLD group were orally administrated at a dose of 7g •kg‐1•d‐1. Rats were killed on the 21st day of tail suspended. The contents of CRH in hypothalamus, ACTH in pituitaria, and CRH, ACTH and CORT in blood were measured. The results showed that the contents of CRH in both hypothalamus and blood were markedly reduced (P<0.01), whereas ACTH in pituitaria ACTH (P<0.05) and COR (P<0.01) in blood significantly enhanced in S and SAI groups as compared with the C group. The concentration of CRH in blood was clearly attenuated (P<0.05), but ACTH in pituitaria had a tendency to increase and ACTH in blood markedly augmented (P<0.01) in SAI group as compared with the S group. The production of CRH in both hypothalamus (P<0.05) and blood (P<0.01) were significantly increased, and ACTH and CORT in blood attenuated (P<0.01) in the TKXLD group as compared with the SAI group. The result demonstrated that the combination of tail suspended and irradiation exaggerated the disorder of HPAA in the rat, mainly manifested by dyspituitarism. It suggests that TKXLD treatment could improve the deleterious effect on the function of HPAA of weightlessness and irradiation during spaceflight.