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Bioequivalence between inhaled hydrogen sulfide and intravenously administered sodium sulfide
Author(s) -
VandenEckart Emily,
Bengtsson Asa,
Johnson Jeff,
Mulligan JoAnne,
Leviten Dina,
Insko Michael,
Mebel Elise,
Vertz Peter,
Toombs Christopher,
Wintner Edward A,
Szabo Csaba,
Deckwerth Thomas
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.749.16
Subject(s) - hydrogen sulfide , sulfide , inhalation , chemistry , pharmacology , sodium sulfide , sodium nitroprusside , anesthesia , sulfur , medicine , inorganic chemistry , organic chemistry , nitric oxide
Hydrogen sulfide is best known as an environmental pollutant and human health hazard. Recently, sulfide has gained recognition as an endogenous biological mediator and is being examined for use as a therapeutic agent. As sulfide may be administered by both inhaled and parenteral routes, the question arises of how exposure to sulfide compares between the two modes of administration. Sprague Dawley rats were exposed for up to two hours of hydrogen sulfide gas up to 400 ppm or received up to 20 mg/kg sodium sulfide by continuous intravenous infusion. Sulfide concentrations in venous blood were quantified as sulfide dibimane derivative. Both modes of administration lead to a dose‐dependent elevation in blood sulfide concentrations over baseline concentrations and reached a new steady‐state concentration within two hours. Steady state blood sulfide concentrations show a simple linear relationship to hydrogen sulfide gas concentration or sodium sulfide dose. Identical blood sulfide concentrations can be achieved by either route of administration suggesting bioequivalency of hydrogen sulfide inhalation and sodium sulfide intravenous infusion in modulating blood sulfide concentrations. This suggests that both modes of administration may exert similar therapeutic effects.