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Hemodynamic patterns and vascular differentiation in embryonal development.
Author(s) -
StypRekowska Beata,
Tabuchi Arata,
Le Noble Ferdinand,
Pries Axel Radlach
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.746.15
Subject(s) - hemodynamics , allantois , anatomy , pulsatile flow , biology , medicine , zebrafish , cardiology , embryo , endocrinology , microbiology and biotechnology , gene , biochemistry
Differentiation of blood vessels into either arteries or veins is not sufficiently understood. Whereas the earliest vascular development appears to be controlled exclusively on the gene level, in later embryonic stages vessels are influenced by hemodynamic and metabolic stimuli. To investigate the role of hemodynamic patterns on vascular development in different vascular beds, we aquired flow patterns in zebrafish embryos and chick chorion allantois membranes (2–4 days post fertilization, dpf). In allantois membrane we observed high pulsatile changes of shear combined with low averaged shear stress in arteries and not in veins. The main vessels of zebrafish embryos undergo a “hemodynamic switch” at 3 dpf. While at 2 dpf arteries and veins exhibit similar hemodynamic profiles with high pulsatility and accelaration, at day 4 vein profiles change and show low amplitude and accelaration. The data suggest the differences of hemodynamic profiles during embryonal development could trigger expression of mechano‐sensitive genes and support arterial‐venous differentiation.