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High‐Fat Feeding Increases Pro‐Inflammatory Cytokines in Type 2 Diabetes
Author(s) -
Sachidanandam Kamakshi,
Eto Chidimma,
Hutchinson Jim,
Ergul Adviye
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.743.8
Subject(s) - adiponectin , endocrinology , hyperlipidemia , medicine , type 2 diabetes , insulin resistance , leptin , diabetes mellitus , obesity , metabolic syndrome , inflammation
Obesity leads to increased circulating levels of pro‐inflammatory cytokines that are secreted by adipocytes, thus increasing cardiovascular risk. Type 2 diabetes often presents along with obesity, insulin resistance and hypertension, leading to a condition called the metabolic syndrome. We hypothesized that diet‐induced hyperlipidemia would worsen inflammation in the Goto‐Kakizaki (GK) rat, a lean model of Type 2 diabetes. Plasma adiponectin, leptin, IL‐6, TNF‐α and MCP‐1 levels were measured in Control and GK rats on regular or high‐fat diet. Adiponectin was decreased in diabetes, although high‐fat feeding normalized it. Leptin, IL‐6 and TNF‐α levels were increased in GK rats, and diet‐induced hyperlipidemia caused further elevation. This correlated tightly with the weight gain and adiposity (fat weight/body weight) in these subsets. Circulating inflammatory markers are good predictors of cardiovascular disease. It is thus important to target obesity/hyperlipidemia and diabetes early on in order to prevent further worsening.