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EXERCISE TRAINING REDUCES BLOOD PRESSURE AND GLOMERULOSCLEROSIS IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Neto Octavio Barbosa,
Bichuette Fabiano,
Silva Debora Tavares Resende e,
Reis Marlene Antônia,
Silva Valdo José Dias da
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.737.41
Subject(s) - medicine , blood pressure , heart rate , propranolol , atropine , mean arterial pressure , cardiology , anesthesia , bradycardia
The aim of the study was to assess the effects of exercise training on baseline arterial pressure (AP), heart rate (HR), autonomic tonus and renal morphology in spontaneously hypertensive rats (SHR). Twenty five male 48–50 weeks‐old SHRs were submitted or not to a swimming protocol, hypertensive sedentary (HS, n=12) and hypertensive trained (HT, n=13) rats. After training, all animals, under anesthesia, had their femoral vessels cannulated. After twenty‐four hours, AP was recorded in baseline conditions during 30 minutes. Following, autonomic blockade of heart was performed using atropine and propranolol. At the end, animals were euthanized and their kidneys were excised for morphologic analysis. Exercise training was able to reduce baseline mean AP (MAP) and HR (123±3 mmHg/334±5 in HT versus 181±4 mmHg/397±9 bpm in HS, p<0.05, respectively). The HT group presented decrease in sympathetic tonus (51±16 bpm versus 138±9 bpm in HS, p<0,05) and increase in vagus tonus (−33±7 bpm versus ‐10±6 bpm in HS, p<0,05). In addition, HT group exhibited smaller glomerulosclerosis indexes (0.07±0.4%) in comparison to HS group (0.13±0.3%, p <0.05). These data indicate that the reduction of baseline AP and HR observed after exercise training affected several autonomic indexes, suggesting a shift of autonomic balance towards a vagal predominance to the heart, which was associated to a concomitant decrease of renal lesions.