Premium
Vasomotor changes in controlled and uncontrolled hypertension
Author(s) -
Frances Maria F,
Zamir Mair,
Usselman Charlotte W.,
Goswami Ruma,
Masse Nick,
Fleischhauer Arlene,
Nolan Robert,
Shoemaker J. Kevin
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.737.18
Subject(s) - blood pressure , cardiology , medicine , pulse pressure , vasomotor , vascular resistance , arterial stiffness , hemodynamics , skeletal muscle , forearm , perfusion , surgery
The relationship between arterial stiffness and cardiovascular disease has been implicated in the development of isolated systolic hypertension. This study tested the hypothesis that hypertension is related to altered vascular mechanics and hence altered hemodynamics in skeletal muscle. The ability to detect such changes was tested using a lumped Windkessel model that incorporates several parameters of vascular control including resistance (R), compliance (C), viscoelasticity (K) and inertance (L). Two groups of middle aged hypertensive individuals were tested, one with normal blood pressure (NBP) following treatment (n=10), and the other with uncontrolled BP (UBP) (n=27). Baseline beat‐by‐beat measures of heart rate (ECG), mean arterial BP (Finometer), and forearm blood flow (FBF; Doppler ultrasound) were collected. Systolic BP, pulse pressure and mean arterial pressure were higher in the UBP group (p<0.01). Furthermore, values of C (0.008 for NBP vs. 0.006 mL/mmHg for UBP; p<0.02) and K (0.161 for NBP vs. 0.233 mmHg/mL/min for the UBP group; p=0.1) indicated that indeed the vessel walls in the UBP group were less compliant and offered more viscous resistance to stretch. Values of R were the same in the two groups. These findings suggest that hypertensive individuals with controlled BP are better able to maintain the function of skeletal muscle vasculature for muscle perfusion. Supported by the Heart & Stroke Foundation of Canada and the Canadian Stroke Network.