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Effects of Alpinia officinarum on LPS‐induced brain injury
Author(s) -
Seok Sun Mi,
Park Tae Yeoup,
Kang Chan Sun,
Lee Tae Gu,
Moon HyoEun,
Jung YiSook,
Baik Eun Joo,
Moon ChangHyun,
Lee Soo Hwan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.734.2
Subject(s) - lipopolysaccharide , rhizome , in vitro , chemistry , pharmacology , inflammation , alpinia , blood–brain barrier , cell adhesion molecule , adhesion , traditional medicine , biochemistry , microbiology and biotechnology , biology , immunology , medicine , central nervous system , organic chemistry
The galangal (the rhizome of Alpinia officinarum, AO) is well known as a traditional herbal medicine in Asia. The present study reported that the chloroform extracts (AOC) of galangal could potentially protect against the blood brain barrier (BBB) collapse by lipopolysaccharide (LPS). Particularly, we confirmed that the increase of BBB permeability caused by LPS was effectively reduced by AOC in vitro BBB model. Moreover, in the increase of leukocyte adhesion caused by LPS, we found that AOC reduced LPS‐induced ICAM‐1, VCAM‐1 and E‐selectin expression at the levels of mRNA and protein in mouse brain microvascular endothelial cells (bEnd.3) and consequent LPS‐induced leukocyte‐adhesion. In addition, we found that the inhibition of these adhesion molecules resulted from the down‐regulation of NF‐κB activity by AOC. These data suggest that AOC may potentially protect from LPS‐induced brain inflammation in bEnd.3. This study was supported, in part, by Gyunggi‐do through CCRB‐GRRC.