Premium
Hyperemic response to different intensities isometric dorsiflexion contractions and brief arterial cuff occlusion
Author(s) -
Sanchez Otto Alexander,
Louie Elizabeth A,
Damon Bruce M
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.730.38
Subject(s) - cuff , isometric exercise , medicine , occlusion , cardiology , reactive hyperemia , nuclear medicine , anesthesia , blood flow , surgery
Reactive hyperemia can induce vascular injuries. The purpose of this study was to compare the changes in blood volume in response to isometric contractions with arterial cuff occlusion of short duration. Methods: apparently healthy subjects. One each testing day, the subjects performed a maximal voluntary contraction (MVC), 50% MVC (50MVC) or 50% MVC with arterial cuff occlusion (50MVC cuff ). MRI data acquisition and analysis : MRI data were obtained on a 3Tusing a dual gradient recalled MRI. Sscans were acquired with TR/TE= 1000/6, 46 ms, slice thickness=7.5 mm, FOV= 18×18, matrix size=128×128, N EX =1. The TE=6 ms and TE=46 ms signal intensities (SI 6 and SI 46 , respectively) plotted as a function of time. The difference between pre and post contraction peak SI (ΔSI) SI 6 and SI 46 reflects changes in blood volume and oxygenation, respectively (1). Statistical analysis : A general linear model repeated measures analysis was performed to test for differences in ΔSI avg , between 50MVC, 50MVC cuff and MVC. Results: ΔSI avg , for TE 6 showed a trend towards a main effect by condition and ΔSI avg , for TE 46 demonstrated a main effect for condition, p = 0.04. Conclusion: This procedure could be used in subjects with muscular weakness and to reduce the potential risk of arterial cuff occlusion of longer durations.