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The Effects of Microcirculatory Responses to Hypovolemic Shock Following Resuscitation with Colloid Solutions
Author(s) -
Mielniczuk Mariusz Jozef,
Krokowicz Lukasz,
Grykien Christopher,
Kusza Krzysztof,
Siemionow Maria
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.730.34
Subject(s) - resuscitation , medicine , shock (circulatory) , albumin , perfusion , hemodynamics , microcirculation , hetastarch , cremaster muscle , anesthesia
Aim of the study was comparison of volume replacement with: 6% Hetastarch (HET), 5% Albumin (ALB), and 10% Pentastarch (PENT) following induction of hypovolemic shock (HS). METHODS: Rat cremaster model was used to evaluate microcirculatory changes after HS induction. Rats were randomized into groups: 1) (n=10) had parameters recorded for 4 hrs; 2) (n=10) blood withdrawn, no replacement; 3) (n=6) replaced with HET; 4) (n=6) replaced with ALB; 5) (n=6) replaced with PENT. During 4 hrs measurements of RBC velocity, vessel diameter, functional capillary perfusion (FCP) and leukocyte‐endothelial interactions, endothelial micropermeability (EMP) were recorded. RESULTS: At 4 hrs after resuscitation with HET, ALB, and PENT respectively 70%, 84%, and 85% return of FCP was recorded compared to 33 % in Group II. ALB and PENT resuscitation reduced level of sticking and transmigrated PMN's. Groups: III, IV, V presented higher tissue oxygenation than Group II (HET – 10.1 ± 0.25, ALB – 12.5 ± 0.28 and PENT 11.2 ± 0.25 vs. Group II 8.1 ± 0.15 mmHg). At 5 hrs after HS, EMP index was: Group I – 0.42; Group II – 0.86; Group III – 0.73; Group IV – 0.82; Group V – 0.7. CONCLUSIONS: After HS resuscitation with Colloid Solutions improved microcirculatory hemodynamics. ALB, and PENT administration decreased level of sticking and transmigrating PMN's. ALB and PENT have beneficial effect on vascular permeability.