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Ultrafine particulates decrease left ventricular performance after ischemia‐reperfusion
Author(s) -
Moll David,
Lindsay John,
Lord Kevin C,
Dellinger Barry,
Dugas Tammy,
Varner Kurt
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.730.23
Subject(s) - ejection fraction , medicine , cardiology , ultrafine particle , oxidative stress , diastole , ischemia , anesthesia , zoology , blood pressure , chemistry , heart failure , biology , organic chemistry
Epidemiological studies show a correlation between increased airborne particulates and hospitalization for cardiovascular events, especially in at risk populations. Ultrafine particles (UFP, <100 nm diam) generated from the combustion of hazardous wastes can contain stable free radicals. Given the link between oxidative stress and cardiac disease, we hypothesized that exposure to UFP may exacerbate left ventricular (LV) dysfunction produced by ischemia reperfusion (I/R). Male Brown Norway rats were pretreated (24 hr) i.t. with UFP containing CuO and dichlorobenzene (DCB, 8 mg/kg), silica UFP (8 mg/kg) or vehicle. Rats were anesthetized, ventilated and a pressure volume (PV) catheter placed in the LV. After baseline measures, the LAD was ligated for 90s and released. PV loops were generated 1–60 min post I/R. At 1 min post I/R, control and DCB‐treated rats showed decreased dP/dt max, increased tau, and increased end diastolic volume. Ejection fraction was unchanged in control and reduced in DCB‐treated rats (−45%). LV performance in control rats returned to baseline by 30 min. In DCB‐treated rats LV performance steadily declined for 60 min before stabilizing at reduced levels (dP/dt, −45%; tau, +38%; EF −50% vs baseline). These data indicate that prior exposure to UFP may pose a significant risk in persons with cardiac ischemia. Support: NIH P20‐ RR018766