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Effects of sibutramine and rimonabant in rats trained to discriminate 22 from 2 hours food deprivation
Author(s) -
Jewett David C.,
Hahn Thomas W.,
Smith Travis R.,
Levine Allen S.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.711.10
Subject(s) - rimonabant , sibutramine , antagonist , stimulus control , cannabinoid receptor antagonist , endocrinology , medicine , anorectic , food intake , pharmacology , psychology , cannabinoid receptor , receptor , weight loss , obesity , nicotine
We tested the effects of sibutramine, a norephinephrine and serotonin reuptake inhibitor, and rimonabant, a CB1 antagonist, in rats trained to discriminate 22 hr food deprivation from 2 hr food deprivation in a two‐lever, operant choice task. After rats acquired the discrimination, subjects were food restricted for 22 hr and administered sibutramine (0.3–10 mg/kg, p.o.) or rimonabant (0.3–10 mg/kg, s.c.). One hour later, the discriminative stimulus effects were assessed. Sibutramine significantly decreased the discriminative stimulus effects of 22 hf deprivation; 3.2 mg/kg reduced the effects of deprivation by 50%. A larger dose eliminated responding and decreased food intake. Rimonabant did not affect the discriminative effects of deprivation, but significantly reduced response rates and decreased food intake. While rimonabant decreases intake and rate of responding it does not alter “hunger” discrimination. Such data support the idea sibutramine affects “hunger‐driven” feeding and that the CB1 receptor is involved in feeding associated with affect/reward, rather than feeding stimulated by energy needs.