Premium
Chlorella vulgaris protects against lead‐induced hepatic toxicity in rats
Author(s) -
Jang Mi Kyung,
Kim In Hye,
Hong Sung Yi,
Om Ae Son
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.709.5
Subject(s) - lead acetate , chlorella , chemistry , chlorella vulgaris , thiobarbituric acid , glutathione , glutathione peroxidase , glutathione reductase , toxicity , superoxide dismutase , oxidative stress , antioxidant , zoology , food science , medicine , biochemistry , algae , lipid peroxidation , enzyme , botany , biology , organic chemistry
This study was accomplished to investigate the effect of Chlorella vulgaris against lead‐induced oxidative stress especially associated with the liver fibrosis. Six weeks old Sprague‐Dawley male rats (n=10/group) were randomly divided into control group (Control; treated with drinking water) and lead‐chlorella groups (Pb+C0, Pb+C2, Pb+C5 and Pb+C10; treated with drinking water containing 200 ppm lead acetate + different concentrations of chlorella 0, 2, 5 and 10% by diet for 4 weeks). Superoxide dismutase activity was decreased in Pb+C0 compared to Control but increased in Pb+C2, Pb+C5 and Pb+C10 (128.9, 165.8 and 167.4% respectively) compared to Pb+C0 (P<0.05). And also glutathione peroxidase and glutathione reductase activity were increased in lead‐chlorella groups compared to Pb+C0 (P<0.05). The glutathione contents were decreased in Pb+C0 compared with other groups (P<0.05). But contents of thiobarbituric acid reactive substances were increased in Pb+C0 (P<0.05). The protein expression of transforming growth factor β1 and matrix metalloproteinase‐2 was significantly increased in Pb+C0 compared to Control but decreased in lead‐chlorella groups. These results indicate that chlorella may have protective effect against lead‐induced hepatic toxicity in rats. [This study was supported by Daesang Co. Ltd. WelLife Health Business.]