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SOX2 immunoreactivity in cortical dysplasia and in tumors with composite glial and neuronal histologic features: Evidence for a common route of histogenesis
Author(s) -
Eschbacher Jennifer Mary,
Coons Stephen William
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.706.38
Subject(s) - histogenesis , ganglioglioma , pathology , cortical dysplasia , immunohistochemistry , biology , dysplasia , medicine , neuroscience , epilepsy
A number of tumors, most commonly dysembryoplastic neuroepithelial tumor (DNET) and ganglioglioma, demonstrate histologic and/or immunohistochemistry features suggesting both glial and neuronal differentiation. The lineage and etiology of these low‐grade glioneuronal tumors is unclear. Based on their similar immunohistochemistry features and common association with cortical dysplasia, we hypothesize that these entities may share a common route of histogenesis. Pleomorphic xanthoastrocytoma (PXA) also demonstrates both glial and neuronal markers. The basis for this, along with its lineage and relation to ganglioglioma, is also unclear. Using immunohistochemistry analysis, we evaluated for expression of SOX2, a neural stem cell marker, in 27 tumors with glioneuronal features and 7 cases of cortical dysplasia. We found scattered SOX2 immunoreactive cells in 22/27 tumors, including 10/10 DNETs, 8/10 PXAs, and 4/7 gangliogliomas. All 7 cases of cortical dysplasia demonstrated SOX2 immunoreactivity in dysplastic areas only. In uninvolved cortex, and in eight normal control autopsy brain sections, we found no SOX2 positive cells. Our results suggest that these entities may share a common lineage and may arise from a multipotent stem cell. This research was funded and supported by Barrow Neurological Institute.