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Myofibroblastoma presenting as a cystic lesion with a mural nodule in the brain parenchyma
Author(s) -
Gaurav Gupta,
Meera Hameed,
Catrambone Jeffrey,
EunSook Cho
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.706.35
Subject(s) - pathology , nodule (geology) , anatomy , lesion , parenchyma , desmin , medicine , cd34 , leptomeninges , vimentin , biology , central nervous system , immunohistochemistry , paleontology , genetics , stem cell , endocrinology
An 18‐year‐old female with no past medical history presented with left sided generalized tonic clonic seizures. Imaging showed a large cystic lesion within the right frontal lobe, just superior to the sylvian fissure. It measured 3.3cm × 4.0cm × 4.1cm. Within this large cystic lesion, there was a homogeneously enhancing lobulated nodule measuring 1.5cm × 1.0cm × 0.9cm. There was edema in the surrounding frontal white matter. At operation the lesion had no attachment to the dura and was completely intraparenchymal. The mural nodule was resected en bloc. Histologically the tumor showed alternating zones of spindle or ovoid cells that were separated by thick collagen bundles. Reticulin fibers are abundant and frequently wrapped around individual cells. Immunocytochemistry showed diffuse positivity for vimentin and focal positivity for bcl 2 and α‐smooth muscle actin. Tumor cells are negative for CD34, desmin, HHF35, S‐100, and EMA. This immunocytochemical profile is consistent with a myofibroblastoma. Myofibroblastoma is a benign mesenchymal tumor, which typically arises in the breast, less frequently in the lymph nodes and in other soft tissue. There are three reported cases of intracranial myofibroblastoma, all of which was attached to the meninges. Current case is unique in that it presented as a mural nodule in a large cyst within the brain parenchyme.