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Evaluation of hormone receptor status and proliferation with a novel isoform of proliferating cell nuclear antigen (ca‐PCNA) in predicting recurrence of pediatric meningioma
Author(s) -
Rushing Elisabeth J.,
Agarwal Beamon,
Man YaoGo,
Santi Mariarita,
Comeaux Jarmon C.,
Hickey Robert J.,
Malkas Linda H.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.706.26
Subject(s) - proliferating cell nuclear antigen , meningioma , immunohistochemistry , pathology , medicine , estrogen receptor , progesterone receptor , biopsy , hormone receptor , estrogen , antigen , biology , cancer , breast cancer , immunology
BACKGROUND Meningiomas are uncommon in children and experience is limited compared to their adult counterparts. Predicting recurrence does not reliably correlate with tumor grade. PURPOSE: To review hormone receptor status and proliferation in 13 cases of intracranial meningioma in children. METHODS AND MATERIALS: Clinicopathologic data were reviewed on thirteen patients (6 females, 7 males) treated for meningioma during a 19‐year period. The patients ranged in age from 8–20 (mean, 15.2 years; SD, 4) years at the time of diagnosis. In all cases, estrogen and progesterone receptor, proliferating cell nuclear antigen (PCNA), ca‐PCNA and Ki‐67 status were analyzed using immunohistochemistry on formalin fixed paraffin sections. On initial biopsy, all meningiomas were grade I, WHO 2007. RESULTS: Four patients developed recurrent disease after a latency period of 1–3 years (mean, 1.6 years, SD, 0.9). The mean Ki‐67 proliferative index was 1; overall, PCNA ranged 10–90% (mean, 66.7) and ca‐PCNA ranged from 10–90 (mean, 32.5). Mean ca‐PCNA value in recurrent meningiomas was 47.2% while in non recurrent it was 17.8%. Staining for hormone receptors revealed that 1–90% of cells expressed progesterone (mean, 34.6%) and none labeled with estrogen. CONCLUSION: There is a positive correlation between ca‐PCNA expression with meningioma recurrence in children.