Premium
Enteral capsaicin lowers the lymphatic absorption of cholesterol (CH) in rats
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.704.2
Subject(s) - capsaicin , lymph , triolein , chemistry , absorption (acoustics) , lymphatic system , oleic acid , endocrinology , medicine , biochemistry , lipase , pathology , physics , acoustics , enzyme , receptor
Capsaicin has been shown to decrease serum CH and fat in rats. This study was conducted to examine if luminal infusion of capsaicin would affect the lymphatic absorption of CH and fat in rats. Adult male rats with lymph cannulae were infused intraduodenally at 3.0 mL/h for 8 h with a lipid emulsion consisting of 20.7 μmol CH labeled with 14 C ( 14 C‐CH), 452 μmol triolein (oleic acid, OA), and 3.1 μmol α‐tocopherol (αTP), and 396.0 ?mol Na‐taurocholate without (control) or with 5.0 mg capsaicin in 24 mL PBS buffer (pH, 6.3). Lymph was collected hourly for 8 h and lymph 14 C‐radioactivity was determined. No significant difference was observed in lymph flow (17.8 ± 3.2 mL/8 h in capsaicin vs. 15.1 ± 1.8 mL in control). However, the lymphatic absorption of 14 C‐CH for 8 h was significantly lower in rats infused with capsaicin (29.8 ± 1.0% dose) than in those infused with the lipid emulsion alone (39.1 ± 3.9%). The results provide evidence that luminal capsaicin reduces the intestinal absorption of CH in rats. The mechanism(s) by which capsaicin reduces CH absorption remains to be determined.