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Effect of CLA isomers on renal injury in the obese fa/fa Zucker rat
Author(s) -
Zhan Yang,
Aukema Harold M.,
Taylor Carla G.,
Zahradka Peter C.,
Ogborn Malcolm R.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.702.36
Subject(s) - glomerulosclerosis , medicine , endocrinology , conjugated linoleic acid , renal function , fibrosis , nephropathy , kidney disease , kidney , chemistry , proteinuria , linoleic acid , diabetes mellitus , biochemistry , fatty acid
Obesity is associated with greater risk and incidence of nephropathy. Mixed conjugated linoleic acid (CLA) isomers have beneficial effects on renal disease, but the effect of individual CLA isomers is not known. Our objective was to test whether dietary CLA isomers would alter renal injury progression in the obese fa/fa Zucker rat. Male obese and lean 17 wk old fa/fa Zucker rats were given diets with either 0.4% c 9, t 11 CLA, 0.4% t 10, c 12 CLA or control diet for 8 wk, after which renal function and histology were assessed. The dietary t 10, c 12 CLA decreased the glomerular volume, worsened the glomerulosclerosis and increased macrophage infiltration compared with control. In the t 10, c 12 CLA group, there was a trend for increased kidney weight, proteinuria, kidney fibrosis and tubular injury (tubular atrophy, calcification and casts) and reduced creatinine clearance, but these were not statistically different from control. The dietary c 9, t 11 CLA group had smaller glomeruli than control, and less glomerulosclerosis, fibrosis and macrophage infiltration compared with the t 10, c 12 CLA group. Hence, t 10, c 12 CLA exacerbates renal injury associated with obesity, while c 9, t 11 CLA does not, and may be protective. (Supported by Manitoba Agriculture Food and Rural Development Initiative, Dairy Farmers of Canada and NSERC)