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Effects of Soy Pinitol on Hepatic Lipid and Antioxidant Metabolism in High Fat Diet‐Fed C57BL/6 Mice
Author(s) -
Choi MyungSook,
Kim HyeJin,
Do GyeongMin,
Park HaeJin,
Shin SuKyoung,
Choi JiYoung,
Jeon JongEun,
Jeon SeonMin
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.698.3
Subject(s) - triglyceride , antioxidant , lipid metabolism , endocrinology , medicine , chemistry , metabolism , cholesterol , insulin resistance , insulin , biochemistry , biology
To investigate the body fat‐lowering, hypolipidemic and antioxidant effects of pinitol supplementation, we carried out to the animal experiment using mice fed high‐fat diet. In these results, 0.05% and 0.1% supplemenation of pinitol significantly suppressed the hepatic triglyceride and cholesterol accumulation, inhibited the hepatic cholesterol biosynthesis and conversion of storage form of cholesterol, and decreased hepatic fatty acid and/or triglyceride synthesis. And also antioxidant metabolism and hepatocytotoxicity were significantly improved by pinitol supplementation. Pinitol, however, did not affect the reduction of body weight or body fat weights, did not improve the plasma lipid profiles and insulin resistance. Accordingly, it is considered that soy pinitol supplementation is not significantly effective to the reduction of body weight and/or body fat, however, it is effective to the protection of hepatocyte and improvement of antioxidant metabolism compared to the HF group. In conclusion, the fucoxathin supplementation with a high‐fat diet seemed to be effective for suppressing body weight gain and for improving plasma and hepatic lipid metabolism in mice.