Premium
Caffeine Intake and Plasma Zinc Levels among HIV+ Adult Drug Users in Miami
Author(s) -
Campa Adriana,
Le Katherine,
Rafie Carlin,
Sales Sabrina,
Baum Marianna K.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.697.7
Subject(s) - caffeine , zinc , zinc deficiency (plant disorder) , medicine , human immunodeficiency virus (hiv) , drug , physiology , endocrinology , pharmacology , chemistry , immunology , organic chemistry
Objective Plasma zinc deficiency, the most common nutrient deficiency in HIV, is linked to disease progression. This study investigated the relationship between caffeine intake and plasma zinc levels of HIV+ drug users. Methods Informed consent, medical history, physical examination, viral load and dietary intakes were collected. 24‐hour recalls were analyzed using Nutritionist IV Diet Analysis program. Results Of the 225 participants, 78% were African American, 62% received ART, and 72% were men. The mean age was 42.6±7.0. The mean caffeine intake was 115 mg. Plasma zinc was inversely correlated with caffeine intake (r = −0.146, p = <0.036). Participants who did not consume caffeine had significantly higher plasma zinc levels compared to those who consumed caffeine (0.673±0.143 μg/ml vs. 0.628±0.125 μg/ml, p = 0.017). Plasma zinc was also higher in participants whose caffeine intakes were below the median (25 mg) compared to those above the median (0.666±0.141 μg/ml vs. 0.630±0.126 μg/ml, p = 0.059). After controlling for age, gender, CD4 count, viral load and ART, caffeine remained significantly associated with plasma zinc, p = 0.0131. Conclusions Caffeine intake during the previous 24 hours was associated with decreased plasma zinc levels. Further research is needed to determine the role of caffeine in affecting plasma zinc levels of HIV+ drug users. Support: Funded by NIDA