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Zinc deficiency‐induced hypertension is not caused by augmentation of renin‐angiotensin system
Author(s) -
Konomi Aki,
Yokoi Katsuhiko
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.697.12
Subject(s) - blood pressure , endocrinology , medicine , renin–angiotensin system , hematocrit , zinc deficiency (plant disorder) , zinc , plasma renin activity , essential hypertension , angiotensin ii , lower blood pressure , chemistry , micronutrient , pathology , organic chemistry
Some scientists reported that zinc (Zn) deficiency induces hypertension, although the mechanism is not established. To investigate the physiological role of Zn in blood pressure control, thirty 3‐week‐old male Sprague‐Dawley rats were assigned into 3 dietary treatment groups of 10 for the 4‐week study: control group (AIN‐93G; Cont), Zn‐deficient group (4.5 mg Zn/kg; ZD) and pair‐fed group (AIN‐93G; PF). At day 24–25, blood pressures (SBP, DBP and MBP) were measured by tail cuff method. At day 27–28, body water distribution was measured. Statistical analysis was performed by PLSD. Blood pressures of ZD were highest and those of PF were lowest among all treatment groups. Blood pressures of ZD were significantly higher than PF. Hematocrit of ZD and PF were significantly higher than Cont, and that of ZD was similar to PF. Peripheral and bone marrow blood of ZD were very sticky and hard to spread on the slide glass. Blood cells were more concentrated in the blood smears of ZD. ACE activity and relative heart weight of ZD were significantly higher than PF and Cont. Ang II and ICW/ECW of ZD were marginally lower than PF. These results suggest that “zinc deficiency hypertension” is not caused by augmentation of renin‐angiotensin system and hemoconcetration. Subsets of essential hypertension in humans might include “zinc deficiency hypertension”. This research was financially supported by Japan Science Society (The Sasakawa Scientific Research Grant No. 18–144)