Premium
Major parameters of zinc (Zn) homeostasis in adult women with a wide range of habitual zinc intake
Author(s) -
Sheng XiaoYang,
Hambidge K Michael,
Miller Leland V,
Bailey Karl B,
Gibson Rosalind S,
Westcott Jamie E,
Lei Sian,
Grunwald Gary,
Krebs Nancy F
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.697.1
Subject(s) - zinc , feces , chemistry , homeostasis , urine , zoology , endogeny , endocrinology , medicine , biochemistry , biology , paleontology , organic chemistry
A clear understanding of optimal public health strategies to prevent human Zn deficiency depends on improved understanding of human Zn homeostasis. Adequate Zn nutrition is of special importance in all women of child‐bearing age. The objective of this study was to measure major parameters of Zn homeostasis in healthy young free‐living adult women with a wide range of total dietary Zn (TDZ, mg Zn/d) and phytate (TDP) based on habitual intake. Methodology included administration of two Zn stable isotopes ( 67 Zn & 68 Zn) intravenously at different times to measure fractional absorption of Zn (FAZ) and endogenous fecal Zn (EFZ, mg Zn/d). A third tracer, 70 Zn, and dysprosium were administered orally with all meals for 6 consecutive days to 24 healthy women. Zn and phytate were measured in duplicate meals, and Zn & Zn isotope ratios in feces and urine. Mean ± SD results included: TDZ 11.7 ± 7.2 mg Zn/d (5.5 – 29 mg Zn/d); FAZ 0.30 ± 0.10; total absorbed Zn (TAZ) 3.0 ± 1.1 mg Zn/d; EFZ 2.7 ± 0.8 mg Zn/d. The slope of linear regression of endogenous zinc in feces + urine vs TAZ = 0.31, r 2 = 0.15, p = 0.081. Fitting TAZ data with a saturation response model gave an A max = 5.5 mg Zn/d, r 2 = 0.60. Calculations from these factorial data were consistent with current EAR for Zn for adult women. Supported by USDA 2003‐00900; GCRC M01RR00051; MO1 RR00069‐41; Science & Technology Commission, Shanghai Municipality 03JC14042.