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Iron supplementation and changes in iron absorption and iron status during pregnancy and lactation
Author(s) -
Woodhouse Leslie R,
Abrams Steven A,
Chen Zhensheng,
Griffin Ian J,
King Janet C,
Mendoza Concepcion,
Mukherjea Ratna,
Viteri Fernando
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.694.1
Subject(s) - lactation , meal , pregnancy , zoology , medicine , endocrinology , chemistry , biology , genetics
Iron supplementation (FeS) is often prescribed for pregnancy. Thus, we assessed the effect of FeS (65mg) on Fe absorption (FeAb) and Fe status during pregnancy and lactation. 3 groups of women were studied: FeS at breakfast (AM; n=13); FeS at bedtime (no food) (PM; n=11); and an unsupplemented group (N; n=10). FeAb was measured at 12–15 (T1) and 32–34 (T3) wks of gestation and at 7–9 wks postpartum (LC). FeAb was measured from the diet and from the supplement (AM group only) using a dual or triple stable isotope method (57Fe labeled bread was given at each meal on the study day, the 65mg supplement (AM group) was labeled with 54Fe, and 58Fe was given IV directly after the breakfast meal). FeAb from the breakfast and the supplement was measured from the relative increases in 57Fe, 54Fe and 58Fe erythrocyte enrichment after 14d. High resolution ICP‐MS with a Ni correction was used to determine Fe isotope ratios after an acid digestion of the erythrocytes. FeAb, (%; p<0.0001), from food for T1, T3 and LC in AM was 6.6 a , 12.3 b & 6.0 a ; in PM was 3.3 a , 12.1 b & 2.5 a ; and in N was 5.2 a , 23.8 b & 3.9 a . FeAb was significantly higher at each time point in N vs. PM (p=0.012). FeAb (%; p<0.02) from the supplement in AM was 2.9 ab , 4.4 b & 1.6 a . [Ferritin], (ln, ug/L, p<0.01) for T1, T3 & LC for AM (47 b , 26 a , 85 c ), PM (40 b , 22 a , 78 c ) & N (47 b , 11 a , 46 b )shows that FeS, continuing into lactation, improves Fe status during pregnancy and lactation. [NIH # R01 HD38805 & WHNRC]