Premium
Does the effect of a short‐term diet and exercise intervention on insulin sensitivity differ between Mexican Americans and nonHispanic whites?
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.685.6
Subject(s) - medicine , insulin sensitivity , insulin , demography , insulin resistance , sociology
Background: We have shown that Mexican Americans (MA) exhibit lower insulin sensitivity (IS) compared to non‐Hispanic whites (NHW), even when matched for fitness and fatness. Possibly ethnic differences also exist in the magnitude of the change in IS in response to a diet and exercise intervention. Objective: We determined the combined effects of exercise and a low‐saturated fat, low sugar diet on estimates of IS in young, non‐obese sedentary MA (n= 16, age=23 y, BMI=25.4 m2/kg) and NHW (n= 19, age=23 y, BMI=25.5). Methods: Participants initially consumed their habitual diets and remained sedentary for 7 days, which was followed by an intravenous glucose tolerance test (IVGTT) to determine the 3‐h insulin area under the curve (IAUC), as well as HOMA‐IR. Immediately following this period, subjects completed a 7‐day diet/exercise intervention (6 sessions,40 min/session at 65% VO2 max) followed by a second IVGTT. Results: Pre‐test measures showed a non‐significantly higher IAUC and HOMA‐IR for the MA compared to NHW. The magnitude of the improvement was similar in both groups (IAUC μU*min/L: MA: pre=2162, post=1471, 32% reduction; NHW: pre=1787, post=1207; 32% reduction; HOMA‐IR: MA: pre=1.18, post=0.783, 34% reduction; NHW: pre=0.975, post=0.729, 25% reduction). These data suggest that the magnitude of IS improvement in response to a short‐term diet and exercise intervention does not differ between MA and NHW.