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Increased dietary protein attenuates C‐reactive protein and creatine kinase responses to exercise‐induced energy deficit
Author(s) -
Blakely Shirley R.,
Blumberg Jeffrey,
O'Neill Karen Rene,
Smith Tracey J.,
Pikosky Matthew A.,
Young Andrew J.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.685.5
Subject(s) - creatine kinase , medicine , creatine , endocrinology , c reactive protein , energy expenditure , inflammation , chemistry
We determined if dietary protein (P) modulates responses of C‐reactive protein (CRP) and creatine kinase (CK), biomarkers of inflammation and muscle damage, during exercise‐induced energy deficit (DEF). Thirteen healthy men (22 ± 1 y, VO 2peak 60 ± 2 ml·kg −1 ·min −1 ) balanced energy expenditure (EE) with energy intake (EI) during baseline (BL) for 4‐d (D1–D4). BL was followed by 7‐d of 1000 kcal·d −1 energy deficit (D5–D11) induced by increased exercise. Throughout D1–D11, kg −1 d −1 . Serum CRP and CK were measured on D4, D5, D6 and D11 while resting after an overnight fast, and again post‐exercise. Both groups experienced a time‐dependent interaction for CRP at fasting and post‐exercise. CRP increased for DEF from D4 to D11 (0.18±0.02 to 0.43±0.3 mg/L, respectively). In contrast, although CRP on D4 was higher for DEF‐P vs. DEF due to dietary protein adaptation, levels decreased from D4 to D11 (3.9±2.2 mg/L to 0.26±0.02 mg/L, respectively). CK increased in both groups on D4 to D6 and was higher post‐exercise than at fasting. CK leveled‐off in DEF and decreased in DEF‐P on D11. These results suggest that increased dietary protein attenuates the CRP response and normalizes post‐exercise CK during exercise‐induced energy deficit. Research funded by Medical Research Materiel Command.