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The effect of almonds on plasma lipids in persons with prediabetes
Author(s) -
Wien Michelle Ann,
Sabate Joan,
MonahanCouch Lynn,
Oda Keiji
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.677.21
Subject(s) - prediabetes , meal , medicine , cholesterol , population , blood lipids , diabetes mellitus , endocrinology , type 2 diabetes , environmental health
Background: Persons with prediabetes are at increased risk of developing cardiovascular disease, yet there is scant research on effective meal planning approaches in this population. Aim and Methods: To evaluate the effect of daily almond consumption on blood lipids of adults with prediabetes, we performed a 16‐week trial in 66 free‐living adults (48 women and 18 men; mean±SE age 53±10 years; BMI 30±5 kg/m 2 ) instructed to consume a background meal pattern yielding 35% fat, 50% CHO and 15% protein. Participants were randomized to consume 20% of energy from almonds (almond‐enriched) or a meal pattern without nuts (nut‐free). Fasting total cholesterol (TC), LDL‐cholesterol (LDL‐C), HDL‐cholesterol (HDL‐C) and triglycerides (TG) were measured at baseline and weeks 8 and 16. Mixed model analysis was performed adjusting for baseline values with all time points included in the model. Results: Daily supplementation with almonds was associated with a greater reduction in LDL‐C [−9% vs. −1% (P=0.03)] and LDL‐C:HDL‐C [−13% vs. −1% (P=0.04) over the 16‐week trial. Almond participants had a significant reduction in LDL‐C [−10% (P = 0.01)] and a significant increase in HDL‐C [+5% (P=0.04)] at week 16 compared to baseline levels, resulting in a significant reduction in LDL‐C:HDL‐C (P=0.001). Conclusion: Daily almond consumption within a defined meal pattern is effective in improving blood lipids in adults with prediabetes.