Premium
Gender specific disease propensities of bone marrow cells from New Zealand hybrid mice
Author(s) -
Jorgensen Trine N.,
MacLeod Megan K.L.,
David Alexandria,
Kappler John W.,
Marrack Philippa
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.667.18
Subject(s) - disease , bone marrow , chimera (genetics) , medicine , autoantibody , endocrinology , biology , immunology , andrology , antibody , genetics , gene
The (NZBxNZW)F1 (BWF1) hybrid mouse is the best analyzed mouse model of SLE. Most female, but only ∼25% of male, BWF1 mice develop SLE‐related symptoms by 1 year of age. Sex hormones may play a role in this disease. To test this, we transferred BM cells from 9 wk old BWF1 mice into lethally irradiated, age‐matched recipients of the same or opposite gender, thus obtaining four groups of chimeras: F→F, M→F, F→M and M→M. Eighteen weeks later, F→F and F→M chimeras had higher levels of serum IgG (3.7 ± 1.8 and 3.4 ± 2.6 mg/ml respectively) than M→F or M→M chimeras (1.9 ± 1.2 or 1.9 ± 1.1 mg/ml respectively). The same was true for the development of renal disease, as it developed statistically earlier in F→F and F→M mice (27 and 30 wk post transfer, respectively) than in M→M and M→F chimeras (>33 wk, p < 0.02). Thus, BM cells from 9 week old female mice have the capacity to drive autoantibody production and renal disease regardless of their subsequent hormonal environment. This study was funded by The Denver Autoimmune Center of Excellence and HHMI.