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TNF α and IGF‐I levels in Down Syndrome (DS)
Author(s) -
Mehta Pankaj D,
Patrick Bruce A,
Dalton Arthur J
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.665.1
Subject(s) - neuropathology , pathogenesis , proinflammatory cytokine , medicine , tumor necrosis factor alpha , neurodegeneration , endocrinology , immune system , disease , cytokine , plasma levels , neurotrophic factors , neuroinflammation , neurotrophin , immunology , inflammation , receptor
TNF α a proinflammatory cytokine, and IGF‐I, the pleiotropic hormone have been involved in the pathogenesis of neurodegenerative diseases. Persons with DS have a number of abnormalities in their immune system. Studies showed that the neuropathology of Alzheimer disease (AD)is always present in individuals with DS 40 years of age and older. We examined levels of TNFα and IGF‐I in plasma from 41 persons with DS (45±8 years old) and 28 age‐matched healthy controls. TNFα levels were higher in DS than controls (p ≤ 0001). Total IGF‐I levels were simlar between DS and controls. However free IGF‐I levels were lower in DS than controls (p ≤ 05). The combined measurements of TNFα and IGF‐I might be useful to monitor anti‐inflammatory or neurotrophic drug effects in DS. It will be useful to determine whehter the levels are useful as biomarkers to predict early signs of AD.