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Id3 controls the developmental window of γδ T cells
Author(s) -
Hayakawa Ikuko,
Zhuang Yuan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.661.3
Subject(s) - t cell receptor , biology , lineage (genetic) , progenitor cell , microbiology and biotechnology , gene rearrangement , t cell , regulator , genetics , gene , stem cell , immune system
T cell progenitors permit active rearrangement at the TCRδ, TCRγ, and TCRβ loci prior to bifurcation of γδ and αβ T cell lineages. In postnatal thymus, majority of these bi‐potential progenitor cells develop into the αβ T cell lineage whereas only a small fraction chooses to adopt the γδ fate. Expression of a fully rearranged and functional TCRβ gene defines the checkpoint for αβ lineage commitment. A substantial fraction of β rearranging cells will not develop further due to out of frame rearrangements. We show here that loss of Id3, a transcription regulator, promotes γδ T cell development from progenitor T cells which have completed TCRβ rearrangement but without producing a functional TCRβ allele. Our data suggests that Id3 may play an important role in shutting off the window of γδ development after the completion of V‐DJβ rearrangement.