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Metabolic Regulation of Long‐Term Potentiation in the hippocampus: Therapeutic Implications.
Author(s) -
Potter Wyatt Benjamin,
O'Riordan Ken,
Burger Corinna,
Roopra Avtar
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.649.5
Subject(s) - ketogenic diet , epileptogenesis , epilepsy , long term potentiation , neuroscience , hippocampus , ampk , anticonvulsant , disease , medicine , biology , protein kinase a , receptor , phosphorylation , biochemistry
Energy supply is critical for essential functions in all cells. There is increasing evidence that dietary carbohydrate and caloric restriction moderate cellular responses to damage, alter ageing processes, enhance longevity and may have therapeutic affects in neurological disorders such as epilepsy, Alzheimer's Disease and Huntington's Chorea. Dietary regimes termed ‘ketogenic diets’ which iso‐calorically replaces carbohydrates with fats and protein, can produce significant anticonvulsant effects in patients with epilepsy and have successfully been used therapeutically. The mechanisms behind the beneficial effects of ‘ketogenic diets’ are completely unknown. We show that signaling pathways heavily implicated in learning and memory, LTP and epileptogenesis are controlled by cellular metabolism via the actions of AMPK. We propose that these mechanisms may underlie some of the beneficial effects of ‘ketogenic diets’ in epilepsy.