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Influence of Complex Nucleotide Substance from baking yeasts on selective cells cytotoxicity.
Author(s) -
Orlova Elena V.,
Orlova Valentina
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.636.1
Subject(s) - hela , cytotoxicity , cytotoxic t cell , apoptosis , cell culture , cancer cell , chemistry , nucleotide , cell , flow cytometry , saccharomyces cerevisiae , microbiology and biotechnology , yeast , biology , cancer research , biochemistry , cancer , genetics , gene , in vitro
It was shown that Complex Nucleotide Substance (CNS) from Saccharomyces cerevisiae been added in final concentration 0.2 ‐1.0 mg/ml to HeLa, U937, MCF7 and L929 cells culture gave cytotoxic effect in all these cell types but not on human leucocytes. CNS also activated caspase‐3 in dose‐dependent manner in all the above cancer cell lines. Under cell‐cytometry investigations CNS increased apoptotic cells quantity and decreased the number of G2/M of all cancer cells lines. Thus, we can conclude that CNS is a selective apoptotic agent and it could give good results in cancer therapy.