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The genes coding for the Lucina pectinata oxygen reactive binding hemoglobins have different structures
Author(s) -
Rivera Linda Edith,
LópezGarriga Juan,
Cadilla Carmen L.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.598.2
Subject(s) - gene , coding region , polyadenylation , intron , biology , genetics , untranslated region , microbiology and biotechnology , gene expression , rna
Lucina pectinata is a mollusk that houses intracellular symbiotic bacteria and produces three types of hemoglobin. HbI is sulfide‐reactive whereas HbII and HbIII are oxygen‐reactive proteins. Their gene structures were examined to understand their evolutionary origin. The L. pectinata HbII and HbI genes contain two introns, interrupting the coding region at position B12.2 and G7.0. The HbIII gene has three introns, including one located 60 bases before the start codon, and two other introns at conserved positions. The 5′UTR and coding regions of HbII and HbIII are identical in length but their 3′UTRs are of different size. The HbII 3′UTR is relatively long when compared with the other globins reported in the literature, including L. pectinata HbI and HbIII. Alternate polyadenylation sites were detected in HbIII and HbII. The L. pectinata Hb genes may be under different cellular controls that direct them to exert their particular functions, which requires characterization, analysis and functional studies of the regulatory elements of the cognate genes.