Premium
Foundational advances in RNA engineering applied to control biosynthesis
Author(s) -
Smolke Christina D.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.529.2
Subject(s) - modularity (biology) , software portability , flexibility (engineering) , computer science , synthetic biology , scalability , living systems , function (biology) , distributed computing , systems biology , computational biology , systems engineering , biochemical engineering , biology , engineering , artificial intelligence , statistics , genetics , mathematics , database , evolutionary biology , programming language
Recent progress in developing frameworks for the construction of RNA devices is enabling rapid advances in cellular engineering applications. These devices provide scalable platforms for the construction of molecular communication and control systems for reporting on, responding to, and controlling intracellular components in living systems. Research that has demonstrated the modularity, portability, and specificity inherent in these molecules for cellular control will be highlighted and its implications for synthetic and systems biology research will be discussed. In addition, tools that translate sequence information to device function to enable the forward design and optimization of new devices will be discussed. The flexibility of the specified framework enables these molecules to be integrated as systems that perform higher‐level signal processing based on molecular computation strategies. The application of these molecular devices to studying cellular systems through non‐invasive in vivo monitoring of biomolecule levels and to regulating cellular behavior, in particular in the control and optimization of biosynthesis, will be discussed.