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Efficient specification of human embryonic stem cells into endoderm derived lineages
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.523.2
Subject(s) - endoderm , embryonic stem cell , biology , stem cell , regenerative medicine , microbiology and biotechnology , cell fate determination , cell type , cellular differentiation , computational biology , cell , genetics , gene , transcription factor
Recent technology advances now make it possible to uniformly differentiate human embryonic stem cells (hESCs) into a range of lineages making it possible to study aspects of early human development that were not previously accessible. Moreover, these methods support the generation of cell types with potential utility in regenerative medicine. Our work has focused on the differentiation of hESCs through a mesendoderm intermediate cell type and then to endoderm lineages which have potential utility for treating diabetes. Signaling pathways involved in cell fate decisions involved in directing hESCs to pancreatic and liver cell types will be discussed.