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Normative data for whole body, femur and lumbar spine bone mineral content in healthy term infants from birth to 1 year of age
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.461.7
Subject(s) - medicine , bone mineral content , dual energy x ray absorptiometry , bone mineral , densitometry , femur , birth weight , gestational age , lumbar spine , nuclear medicine , gestation , osteoporosis , surgery , pregnancy , biology , genetics
The use of bone mineral densitometry is increasingly used to evaluate bone disease in pediatrics; however, interpretation is difficult due to a lack of appropriate reference data. A prospective study was conducted to assess bone mineral content (BMC) in infants born at term (37 to 42 weeks gestation), weight appropriate for gestational age, and free of congenital malformations. The group consisted of 33 boys and 26 girls recruited from the Winnipeg Health Sciences Center (Manitoba, Canada). Whole‐body (WB), lumbar spine (vertebrae 1–4) and femur BMC were measured using dual‐energy x‐ray absorptiometry (DXA; QDR 4500A, Hologic Inc., Waltham, MA) in array mode. All measurements of BMC increased linearly over the study period (Table 1). WB BMC adjusted for weight increased (p<0.01) by 12% during the year. After adjusting for weight, both spine and femur decreased (p<0.01) by 30% and 15%, respectively from baseline to 6 months. Relative to 6 months, by 12 months BMC of spine increased (p<0.01) by 16% and femur (p<0.01) were no longer different from baseline values. There were no differences in BMC between boys and girls after adjustment for total weight. This data represents the accretion of BMC during the first year of life and will aid in the interpretation of diagnostic DXA scans in pediatrics.