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Anthocyanin Bioavailability from Acute Cranberry Juice Consumption and Evidence of Effects on Endothelial Function in Patients with Coronary Artery Disease
Author(s) -
Milbury Paul E.,
Vita Joseph A.,
Finnerty Kathryn A.,
Holbrook Monika,
Palmisano Joseph,
Hamburg Naomi M.,
Blumberg Jeffrey B.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.460.5
Subject(s) - bioavailability , medicine , coronary artery disease , cranberry juice , anthocyanin , flavonoid , cardiology , brachial artery , endothelial dysfunction , polyphenol , endothelium , food science , chemistry , pharmacology , blood pressure , biochemistry , urinary system , antioxidant
Observational studies suggest that intake of flavonoid‐rich foods reduces the risk of cardiovascular disease. To test the hypothesis that cranberry anthocyanins are bioavailable and affect endothelial function, a pilot study was undertaken in 15 patients (age: 62±8 y) with coronary artery disease. Blood and urine were collected between baseline (0 h) and 4 h after consumption of 480 mL cranberry juice (54%; 835 mg total polyphenols). Marked inter‐individual differences in plasma anthocyanin pharmacokinetics (determined by HPLC) were observed with maximum concentrations detected between 1–3 h. Endothelium‐dependent flow‐mediated dilation (FMD) was measured in the conduit brachial artery by ultrasound and in small fingertip arteries by pulse amplitude tonometry (PAT). Cranberry juice increased FMD (7.7±2.9 vs. 8.7±3.1%; p≤0.01) and log PAT ratio (0.10±0.12 vs. 0.23±0.16; p≤0.001) at 0 and 4 h after juice consumption, respectively. Hyperemic flow and baseline arterial diameter remained unchanged. Thus, cranberry anthocyanins are bioavailable and endothelial function improves following consumption of cranberry juice in patients with coronary artery disease. Research support: Ocean Spray, Inc. and USDA 58‐1950‐7‐707.