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Correction of dyslipidemia resulting from high fat diets with purified anthocyanins from blueberry or strawberry but not in context of the complete berry
Author(s) -
Prior Ronald L.,
Wilkes Samuel,
Wu Xianli
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.460.2
Subject(s) - triglyceride , berry , dyslipidemia , chemistry , food science , context (archaeology) , cholesterol , endocrinology , biology , obesity , biochemistry , botany , paleontology
Male C57BL/6 mice received diets with either 10% kcal from fat (LF), a high fat diet [45% (HF45) or 60% (HF60) kcal from fat]. In the first study the diets were prepared with or without freeze dried powders from whole blueberries (BB) or strawberries (SB). In the 2nd study, a LF or HF60 diet was fed and purified anthocyanins (ACNs) from SB or BB (1 mg total ACN/mL) were added to the drinking water of the treatment groups fed HF60 diet. In Study 1, when whole SB or BB powder was included in the diet, plasma triglycerides were increased by feeding the HF diet but were elevated further when BB was included in the HF diet. Liver total lipids and triglycerides were increased in mice fed HF diet but were not altered by either SB or BB in the diet. Liver cholesterol was not altered by dietary fat level or SB or BB in the diet. In the 2nd study, after 8 weeks mice fed the HF60 diet plus purified ACNs from BB or SB in the water, had lower body weight gains and body fat than the HF60 fed controls. Remarkably, plasma cholesterol (mg/dL) was 128±12, 238±20, 151±18, and 166±10 and triglycerides (mg/dL) were 173±23, 312±39, 168±16 and 154±33 in LF Control, HF60, HF60‐BB and HF60‐SB, respectively. Plasma cholesterol and triglyceride levels were elevated with a high fat diet and decreased to control levels when purified ACNs from either SB or BB were included in the drinking water. Purified ACNs prevented the development of obesity, but not in the context of the whole berry.