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Cortisol Changes with Weight Loss and Affects Food Intake from a Buffet
Author(s) -
Witbracht Megan Gage,
Olney Deanna K.,
Horn William F.,
Adams Sean H.,
Keim Nancy L.,
Laugero Kevin,
Van Loan Marta
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.459.7
Subject(s) - medicine , endocrinology , weight loss , ingestion , bedtime , saliva , circadian rhythm , rhythm , zoology , food intake , obesity , biology
The purpose of this study was to determine if weight (wt) loss alters cortisol (COR) rhythm and if an association exists between [COR] and self‐selected food intake following an energy‐restricted diet. Obese men (n=2) and women (n=14) participated in this 15‐wk trial. All foods/beverages were provided and measured to achieve wt maintenance during 3‐wk baseline and wt loss during 12‐wk energy‐restriction (500 kcal/d reduced). Wt, body fat, intra‐abdominal fat (IAAT) were measured, and subjects participated in a test protocol that included ingestion of standardized breakfast and lunch and an ad libitum buffet‐style dinner at wks 3 & 15. Saliva was collected 10 times from waking to bedtime on test days. At wk 15 significant changes in wt, fat mass and IAAT occurred and averaged −6.4 ± 0.8 kg, −5.2 ± 0.6 kg, and −7.6 ± 1.6 cc. Peak salivary [COR] was reduced significantly, from 17.12 ± 1.99 at wk 3 to 12.97 ± 1.10 nmol/L at wk 15. Times of peak and nadir COR did not differ at wks 3 & 15, suggesting the absence of phase shift in COR rhythm. Buffet food intake was variable (kcal range=572 to 2636). Salivary [COR] measured immediately before and 30 min after dinner were positively associated with kcal intake (r=.50; p<0.05) and (r=0.72; p<0.01). Energy restriction and/or wt loss is associated with change in amplitude of COR rhythm. Also, [COR] around the meal and kcal consumed at the meal influence one another. Funded by Dairy Mgmt Inc & USDA.