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Homocysteine lowering with folate, vitamin B12 and vitamin B6 does not alter the proportion of n‐3 long chain polyunsaturated fatty acids (LCPUFA) in plasma phosphatidylcholine.
Author(s) -
Crowe Francesca,
Skeaff C Murray,
Williams Sheila,
Green Tim
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.449.3
Subject(s) - homocysteine , phosphatidylcholine , docosapentaenoic acid , vitamin b12 , docosahexaenoic acid , plasma homocysteine , medicine , polyunsaturated fatty acid , eicosapentaenoic acid , endocrinology , chemistry , placebo , vitamin , biochemistry , fatty acid , phospholipid , alternative medicine , pathology , membrane
There is evidence to suggest that folate, homocysteine or both affect tissue n–3 LCPUFA composition. We aimed to determine whether homocysteine‐lowering with folate, vitamin B 12 , and B 6 affect the tissue composition of n‐3 LCPUFA in plasma phosphatidylcholine. We conducted a randomized placebo controlled clinical trial involving 253 participants, 65 y or older, with plasma homocysteine concentrations of at least 13 μmol/L. Participants in the vitamin group (n=127) took a supplement containing 1000 μg folate, 500 μg vitamin B12, and 10 mg vitamin B6 for 2y. The fatty acid composition of plasma phosphatidylcholine was measured at baseline and at 2 y. Plasma homocysteine concentrations during the course of the study were, on average, 4.4 μ mol/L lower in the vitamin group than in the placebo group. There were no significant differences in the proportion of eicosapentaenoic, docosapentaenoic or docosahexaenoic acids in plasma phosphatidylcholine between the vitamins and the placebo group at 2 y; the differences after adjusting for baseline values and sex were −0.03 (99% CI: −0.22, 0.16), 0.03 (−0.03, 0.09) and −0.02 (−0.27, 0.24) mol%, respectively. Lowering plasma homocysteine concentrations with B‐vitamins had no effect on the proportion of n‐3 LCPUFA in plasma phosphatidylcholine.