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OXIDATIVE STATUS IN HEAVY SMOKERS: EFFECT OF NUTRITION SUPPLEMENTS
Author(s) -
Bamonti Fabrizia,
Novembrino Cristina,
Gregori Dario,
Lonati Silvia,
Schiraldi Gianfranco,
Cighetti Giuliana
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.445.6
Subject(s) - oxidative stress , malondialdehyde , lipid peroxidation , placebo , reactive oxygen species , antioxidant , chemistry , oxidative damage , food science , oxidative phosphorylation , medicine , antioxidant capacity , cigarette smoking , endocrinology , biochemistry , pathology , alternative medicine
Long‐term cigarette smoking can cause oxygen free radical (ROS) formation and antioxidant capacity depletion, leading to oxidative stress involved in many disorders. Active ROS produces lipid peroxidation generating molecules such as oxidized LDL (oxLDL) and malondialdehyde (MDA) used as indexes of oxidative damage. An adequate diet and/or supplementation may attenuate this condition. To evaluate potential beneficial effects of supplementation with two different encapsulated formulas, consisting primarily of mixed juice powder concentrate, a placebo‐controlled double‐blind study was performed on 61 heavy smokers (>20 cigarettes/d, duration ≥10y, age 40–60y, 35 male). Subjects were randomized into 3 groups: A‐placebo; B‐fruit/vegetable; and, C‐fruit/vegetable/berry. We measured serum oxLDL and plasma free MDA (f‐MDA), the chemically active form, index of recent damage. Values (mean±SD) were compared at baseline (T0) and after 3 months supplementation (T1). Nutritional supplementation produced a decrease in oxidative damage indexes, more evident in group C than B, and seems to attenuate smoking effects. Support: NSA, Collierville, TN