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Canine dietary protein influences glomerular filtration rate in adult dogs
Author(s) -
Jewell Dennis E.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.444.1
Subject(s) - renal function , lean body mass , endocrinology , medicine , chemistry , iohexol , urology , zoology , body weight , biology
Seventy normal adult dogs were randomly assigned to five dietary protein levels with and without amino acid fortification. This study was run to determine the effect of different protein and amino acid concentration on renal function as measured by glomerular filtration rate (GFR) and body composition in a six month study. The experimental protocol was reviewed and approved by the Institutional Animal Care and Use Committee. Dogs had daily socialization through interacting with other dogs and daily walks with people. Glomerular filtration rate was measured by iohexol clearance while body composition was determined via dual energy x‐ray absorptiometry (DXA). GFR and DXA were measured before and after six months on treatment. Foods were formulated to contain 15, 19, 22, 25, or 30% protein. All treatments had numeric increases in body lean but change in lean was not influence by diet. Dietary protein had a significant quadratic and linear effect (P<0.05) on GFR. Increased GFR was attained through either increasing above or reducing below 21% protein. These data show that renal function as measured by GFR may be increased with increasing protein and through restricting excess protein.