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Dietary Calcium and dairy modulation of oxidative stress and life span in mice
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.442.4
Subject(s) - calcium , oxidative stress , endocrinology , reactive oxygen species , medicine , adipose tissue , lactation , chemistry , obesity , zoology , biology , biochemistry , pregnancy , genetics
Dietary Ca attenuates adiposity, blood pressure, reactive oxygen species (ROS) production and inflammatory stress, while milk exerts a greater effect than supplemental Ca. Since these effects have the potential to extend lifespan, we fed aP2‐agouti transgenic mice (a model of diet‐induced obesity) and littermate controls a low Ca (0.4% Ca), high‐Ca (1.2% Ca from CaCO3), or milk (1.2% Ca from non‐fat dry milk) obesigenic diet until their death to examine the effects on lifespan and related biomarkers. Randomized subgroups were sacrificed at 28, 52 and 78 weeks of age for biomarker analysis. Weight gain in the milk group was 46% (p=0.003) lower than in controls, and this was associated with a decrease in adiposity (p<0.035) and higher muscle mass (p=0.032) with increasing age. The Ca and milk diets reduced adipose tissue ROS production and the age‐related rise in ROS, with a significantly greater effect from milk (p<0.005). Survival analysis to date demonstrate a significant protective effect of the milk, but not the calcium diet; the 75% survival rate for wild type mice is 546 days for the milk, compared to 483 days (p=0.014) and 424 days (p=0.018) in the control and high calcium groups. Accordingly, high Ca diets attenuate age‐related ROS production, while milk, but not supplemental calcium, increases lifespan compared to mice fed Ca‐restricted diets. Supported by The National Dairy Council.