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Regenerative medicine: enabling technologies for clinical translation
Author(s) -
Yoo James J.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.389.1
Subject(s) - regenerative medicine , tissue engineering , regeneration (biology) , function (biology) , process (computing) , biocompatible material , biomedical engineering , nanotechnology , computer science , medicine , stem cell , biology , materials science , microbiology and biotechnology , operating system
Tissue engineering and regenerative medicine has emerged as an innovative scientific field that focuses on development of new approaches to repairing cells, tissues and organs for clinical applications. Recent advances in this field have offered new therapeutic opportunities that facilitate the restoration and maintenance of normal tissue function. Consistent with the goals of tissue engineering and regenerative medicine, we have followed a strategy that has shown to be effective clinically. This approach involves the use of biocompatible matrices either with or without cells. The matrices are either used as cell delivery vehicles or as scaffolds to promote and enhance tissue regeneration. When cells are used, donor tissue is dissociated into individual cells, which are expanded in culture, attached to a support matrix, and reimplanted into recipient for recovery of tissue function. Over the past years, research investigations have been actively pursued in various tissue systems using tissue engineering and regenerative medicine concepts and technologies. Although these tissues have shown their potential applicability experimentally, only a limited number of tissues have been successfully engineered for clinical use to date. This is due to various obstacles encountered in the tissue building process. The progress toward clinical translation, current challenges hampering organ development and potential solutions to overcome technical hurdles will be discussed.