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Pathobiology of ovarian epithelial cancers (OEC) in relation to age‐specific incidence rates (ASIR)
Author(s) -
Grimley Philip M,
Henson Donald E,
Schwartz Arnold M,
Anderson William F
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.321.1
Subject(s) - serous fluid , population , medicine , pathology , oncology , environmental health
The pathogenesis of OEC is being critically explored by molecular profiling. We propose that population‐based analyses of OEC can link traditional histopathologic subclassification to underlying molecular events. NCI Surveillance, Epidemiology, and End Results registries provided data for > 35,000 cases of OEC from >14 % of the US population for the years 1992‐2004. When ASIR (as cases per 100,000 woman‐years) are analyzed by log‐log plots (LLP), the exponential graphs express cumulative age‐dependent events. Thus, similar graphical patterns suggest a common pathogenesis, while different patterns imply etiologic heterogeneity. Results : For serous OEC, trajectories of LLP, including ages of ASIR inflection (flattening), reproducibly discriminated between subsets of low and high pathologic grade. This appeared congruent with a dichotomy in oncogenesis (Singer et al. Am J Pathol, 2002). In contrast, ASIR for all grades of mucinous OEC showed parallel trajectories of LLP with late age inflections. For OEC recorded as endometrioid, clear cell, undifferentiated, papillary‐, adenocystic‐ or adeno‐ carcinoma, graphical patterns were inconsistent with those of the serous or mucinous subsets. Summary : LLP analyses of ASIR for classical OEC revealed distinct graphical patterns for high and low grade subsets of serous carcinoma. This accords with reported molecular signatures. Supported by USUHS and GWCI.